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These pharmacokinetic limitations explain why the most successful applications have been topical (where the peptide is applied directly to the target tissue) rather than systemic

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This may be due to various study limitations, such as variability of the study populations, non-homogeneous groups, unspecified sample size, different analytical methods employed, and transportation of selenium to the fetus: thus, conclusions about causal relationships cannot be drawn [27]

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Serum leptin levels were also negatively associated with overall survival of ALS patients 4