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In some cases, people may lose muscle along with weight

GLP1 therapies can deliver impressive weight loss (15%), but most people regain weight after stopping treatment (Panel A)

Injection site rotation schedule A simple rotation pattern prevents tissue damage and ensures consistent absorption

Furthermore, metabolic stressors, such as hypercholesterolemia, have been reported to promote BBB disruption, with increased permeability and decreased claudin-5 and occludin transcription (de Oliveira et al., 2020)