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First, it has been shown in various types of cancer such as breast, prostate, and lymphoma that iron metabolism can be reprogrammed either by the upregulation of several iron intake pathways or the downregulation of iron export and storage pathways (100, 101)

Genistein reactivates the Keap1/Nrf2 pathway, thereby increasing the levels of antioxidant proteins like heme oxygenase 1 (HO-1) and NAD(P)H quinone dehydrogenase 1, which reduce oxidative damage (Hu et al., 2021)

The penetration is unconfirmed at the site that matters

Evaluation of total GST activity The results indicated that while docetaxel did not affect GST activity, chlorophyllin administration alone inhibited the GST activity significantly in tissues compared to the control

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy