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The article says eligibility often turns on underlying metabolic risk rather than weight alone, and names elevated fasting glucose, prediabetes, insulin resistance, elevated triglycerides and a family history of type 2 diabetes as factors that can make a lower-BMI patient a candidate

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Meta-analyses and large trials report high rates of nausea, vomiting, diarrhea, and constipation in treated youths, typically mild to moderate in severity and diminishing over time ( While generally safe, GLP-1 RAs carry a few serious but uncommon risks that clinicians must be aware of and monitor

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Theres some evidence the supplement may be particularly helpful for people with insulin resistance who have polycystic ovary syndrome (PCOS), a hormonal condition that interferes with periods and the ovaries