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Based on these results, we propose that inhibition of RNR (or upstream enzymes) leads to accumulation of GSH which can be re-purposed for use by GPX4 to prolong the inhibition of ferroptosis under conditions where new GSH synthesis is otherwise impossible (Fig 6)

Zhang W, Yang S, Cui L, Zhang J (2016) Neutrophil gelatinase-associated lipocalin worsens ischemia/reperfusio n damage of kidney cells by autophagy

Melatonin can be given to children over the age of six for sleep management if other methods have failed