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A BMI of 30 or higher qualifies only alongside heart failure with preserved ejection fraction, uncontrolled hypertension, or chronic kidney disease at stage 3a or above
Lesions of dopamine nigral neurons not only result in depression-like behavior (in the substantia nigra pars compacta) but also lead to a cascade of functional modifications on the activity of basal ganglia circuits, with the dysregulation of the glutamate system.12,13 This pathophysiological mechanism is also shared with Parkinson's disease, with the destabilization of the brain reward mechanism being linked to an increased risk of DE relapse.14 Note, the higher frequency of cardiovascular disorders than in other patients is also associated with the decrease in the activity of GDH, the glutamate-metabolizing enzyme
Given that fertility involves both partners, the mans weight loss and health improvement on a GLP-1 RA may actually increase the couples chance of conception (and certainly will improve his overall health)
- Manage Stress: Stress can make digestive symptoms worse, so finding ways to relax, like yoga or meditation, can be really helpful
