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Efficacy, safety and impact on -cell function of dipeptidyl peptidase-4 inhibitors plus metformin combination therapy in patients with type 2 diabetes and the difference between Asians and Caucasians: a meta-analysis

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Both GLP-1R and GIPR belong to the class B GPCR family and signal primarily through the GscAMP pathway to promote glucose-dependent insulin secretion from pancreatic -cells

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showed no differences in the frequency of symptomatic hypoglycemic events or severe hypoglycemia ( As insulin doses are reduced to prevent hypoglycemia, there is also a potential risk of hyperglycemia and eliciting diabetic ketoacidosis