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doi: 10.1017/S0033291723002283 23 McLeanB

Injections are given subcutaneously (just under the skin), and injection sites should be rotated daily to prevent lipoatrophy or irritation

3,4 The first official diagnostic guidelines were published in 1990 by the American College of Rheumatology, followed by treatment guidelines published by the American Pain Society in 2005

doi: 10.1056/NEJMoa1901118 10 MannJFErstedDDBrown-FrandsenKMarsoSPPoulterNRRasmussenSet al

Where appropriate, we also draw on harm reduction principles, meeting people where they are rather than demanding immediate perfection in their relationship with food or their body