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Hypoglycemia or fluctuations in insulin signaling can exacerbate neuropathic pain by increasing oxidative stress and dysregulating sodium-potassium ion channels in sensory neurons

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The PK stability profile in mice of our early fusions such as Ab#2_GLP1 and Ab#2_EX4 demonstrated that the in vivo GLP-1R activity of such peptide-antibody fusion molecules rapidly decreased over time due to peptide degradation compared to the exposure achieved by the antibody Fc component (Fig

More recent meta-analyses confirm that digital self-monitoring, delivered via apps, wearables, or electronic scales, produces moderate weight loss and improves adherence compared to paper-based approaches, with higher engagement linked to greater weight reduction [91, 92]