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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind

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It has been extensively characterised in preclinical in-vitro and in-vivo models for its cytoprotective, angiogenic, and anti-inflammatory properties across a range of tissue types

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The accumulation of soluble protein, especially for the heat shock proteins during heat stress, contributes to stress tolerance in plants 30