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Patients losing weight rapidly (more than 1 to 2 pounds per week sustained over months) are at higher risk because the mechanical unloading signal to bone is more acute

FDA-approved branded medications through traditional healthcare: Products such as Wegovy, Ozempic, Zepbound, and Mounjaro have undergone comprehensive FDA review for safety, efficacy, and manufacturing quality

Histone deacetylases (HDACs), as key epigenetic regulators, also possess essential functions in regulating iron metabolism and ferroptosis

Metformin can increase the risk of lactic acidosis in the setting of excessive alcohol intake, as alcohol impairs the liver's ability to clear lactate