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Rotate injection sites Repetitive injections in the same spot can lead to side effects such as the development of lumps under the skin, which can irritate and cause discomfort

It may result in increased statistical errors due to low test power

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A key advancement in addressing these mechanisms is the shift from a neuron-centric to a holistic view that encompasses the critical role of glial cells, a perspective that informs the diverse therapeutic toolkit explored in the following sections

Similar recommendations were made by the European Medicines Agency (EMA) that required including major adverse cardiovascular events (MACE) as a primary endpoint ( These regulatory requirements led to the discovery of cardiovascular benefits in GLP-1R agonists, demonstrating the importance of due diligence and proactive safety monitoring