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The enzyme uses either iron or manganese as a cofactor and catalyzes the degradation or reduction of hydrogen peroxide (H2O2) to water and molecular oxygen, consequently completing the detoxification process imitated by SOD.35, 36 It is abundant in cells, where it continuously scouts for hydrogen peroxide molecules

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5-Amino-1MQ is the lead potent, selective small-molecule inhibitor of NNMT identified to date

In 2019, an internal medicine specialist could not find an objective cause for his B12 deficiency, and supplementation was stopped