(9) Combining high doses of vitamin C with caffeine, which can also affect the digestive system, might increase the risk of these side effects
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Nickels JD, Cheng X, Mostofian B, Stanley C, Lindner B, Heberle FA, Perticaroli S, Feygenson M, Egami T, Standaert RF, Smith JC, Myles DAA, Ohl M, Katsaras J (2015) Mechanical properties of nanoscopic lipid domains
Additionally, questions exist about potential effects in this population, including the impact of rapid weight loss on skin elasticity and lymphatic function in areas already affected by tissue changes