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37 They are used when 2 ligands and SNRIs are ineffective or contraindicated

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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017

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Its sterile, pH-balanced formulation ensures minimal cytotoxicity and maintains redox integrity, making it uniquely suited for high-resolution studies of antioxidant defenses, phase-II enzyme kinetics, and inflammation-resolution pathways in both cell-culture and animal models