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For the majority of patients, gastrointestinal side effectsthe most common categorytypically peak during the first 48 weeks of treatment or following dose escalation, then gradually diminish over subsequent weeks as physiological adaptation occurs
Most people stay at each dose for at least four weeks
Subgroup analyses Figure 3 showed the results of the subgroup analyses for age, sex, BMI, HbA1c, GFR, previous myocardial infarction or cerebral infarction, heart failure, and hypertension
They were also introduced to start with regular exercise