The molecule is engineered for this: it is attached to a fatty-acid chain that binds to albumin (a protein in your blood), which slows its breakdown and stretches the dosing interval to once weekly
This protein denaturation may be beneficial to inactivate antinutritional factors such as egg-white antiproteases but also to denature highly resistant proteins, thereby facilitating protease activity in the digestive tract
You may experience different side effects with Welchol depending on whether you have high cholesterol, type 2 diabetes, or both
However, in pancreatic tumours, this substrate is more derived from the contribution of glutamine, which is worth further exploration in the future (60)
Therefore, considering the balance between the hydrophobic and hydrophilic regions in the polymer is crucial for NP performance in antibiotic delivery