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Weight-related comorbidities that qualify include type 2 diabetes, hypertension (high blood pressure), dyslipidemia (high cholesterol or triglycerides), obstructive sleep apnea, cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis of weight-bearing joints

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Over the years, methods have been refined into the most commonly used protocol today, which uses an acid/ethanol precipitation (to disrupt the IGF-1/IGFBP complex) followed by the addition of insulin-like growth factor-2 (IGF-2) to prevent the reformation of the IGF/IGFBP complex

Tirzepatide is a novel dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor agonist recently approved for diabetes and weight loss