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It is a well-characterized, mechanistically specific peptide with a 30-year research history, a strong clinical safety record from formal trials, and modest but real efficacy data from 12-week studies

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Upon viral infection, the ISG tripartite motif 14 (TRIM14) directly binds to the C-terminus of cGAS and recruits ubiquitin-specific peptidase 14 (USP14) to prevent K48-linked ubiquitination and degradation of cGAS

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