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Stratikopoulos and colleagues 21 produced a mouse model in which IGF-I cDNA is regulated under a native promoter/enhancer of IGF-I gene only in liver on an Igf1 null background, and revealed that endocrine IGF-I contributed approximately 30% of the adult mouse body size

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It tends to develop more gradually during titration and affects food preoccupation in addition to physical hunger

Acta Pediatr 1996, 85: 11347