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In the US, Novo expects a sales decline in the teens, driven by three forces: deliberate price reductions to expand market access the shift toward the cash-pay channel at lower price points the Most Favoured Nations agreement with the Trump administration Internationally, the picture is somewhat better, with expected mid-single digit growth, though dampened by loss of exclusivity for semaglutide in markets such as Canada and China

Inflammatory cytokines, such as IL-1, have been shown to induce ferroptosis in chondrocytes

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Marinoni et al., 2022)