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For example, vagus nerve activity and its ability to stimulate brainstem neurons are dependent on the presence of the gut microbiota and its metabolites [261]

GLP-1 can improve abnormalities in glucose metabolism and excessive lipid accumulation by modulating the activity of FOXO1.5,514 Sirt1, a protein deacetylase, plays a key role in delaying cellular aging and regulating metabolism.515,516,517 GLP-1 may improve the livers antioxidant capacity and metabolic function by activating Sirt1, thereby helping to alleviate the pathological changes associated with NASH

Studies show that GLP-1 receptor agonists, drugs that mimic GLP-1, have been shown to help people with type 2 diabetes (T2D) and obesity lose weight and control their blood sugar [2]

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Gao, W., Wang, J., Yin, S., Geng, C