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However, the phenomena that induce OS attributable to the patients aging, in addition to being variable in terms of intensity among individuals, are difficult to distinguish from those produced by the compromised antioxidant defense systems due to a neurodegenerative disease, such as ALS

They talk about areas of concern and realistic outcomes

Glutathione S-transferases (GSTs) may also be involved in conjugating electrophiles generated from the reaction of hydroxyl radicals with lipids and DNA, and thus contribute to oxidative stress resistance (Marrs, 1996)