is glp-1 real Real-World Evidence for Receptor Agonists Across the CKD Spectrum – AJKD Blog GLP-1 and Anesthesia: Considerations and

2013 Jun;143(6):818-26

The compounds selective mechanism provides advantages for research that requires growth hormone stimulation without broader hormonal effects

A negative nitrogen balance did not occur in healthy adults during a short period (e.g., 8 days) of consuming a histidine-free diet because the hydrolysis of histidine-rich hemoglobin in blood and of carnosine in skeletal muscle provides histidine for protein synthesis in tissues at the expense of health

Progress should be tracked with symptoms and function changes

Ensuring Healthy Weight Loss The researchers ultimately conclude that GLP-1 drugs significantly reduce body weight and adiposity, along with a substantial FFM [fat-free mass] loss, but with no clear evidence of CRF enhancement. They remain concerned that this could take a toll on patients metabolic health, healthspan/frailty and overall longevity