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Now free from the FOXO4 thats stuck in the nucleus, the p53 and FOXO4-DRI combo could drift to the mitochondria where p53 could do its work and the cell would undergo apoptosis senescent cells could finally die

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164 The proportion of responders rose from 33.3% at week 1 to 90% one month after completion of 12 instillations and then diminished to 16.7% by 6 months after the last instillation