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Chronic GSH deficiency by Gclm deletion in mice has also been associated with metabolic alterations and the activation of the stress-responsive factor AMPK 53,84

Mitchell, S

The oxidative branch of the pentose phosphate pathway (PPP), driven primarily by the enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), continues to serve as the dominant metabolic source of NADPH in most cells [42]

The combination of tirzepatide's metabolic effects and resistance training's muscle-preserving effects produces body composition changes that neither achieves as effectively alone

& Chang, A