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This approach can also result in increased production of other hormones produced by L-cells such as oxyntomodulin and peptide YY (PYY), which can enhance the metabolic effects of GLP-1
As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells
By providing butyrate directly as a postbiotic supplement, patients can bypass the need for colonic fermentation to produce this beneficial compound, which is particularly valuable when the microbiome is disrupted
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