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esRAGE generation not only means inflammatory signaling is prevented due to decreases in intracellular signaling but the esRAGE also prevents cognate ligands from binding any remaining mRAGE, PLUS binding to other receptors, including TLRs

This can alleviate symptoms and promote healing

Glucocorticoid abnormalities in female rats exposed to a predator-based psychosocial stress model of PTSD

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