This involves the removal of electrons from lipids, resulting in lipid peroxidation and, consequently, cellular damage [34]
Collagen loss, oxidative stress, barrier weakening, expression-line deepening
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In particular, the observed changes in MAPK- and Rap1-related pathways are biologically plausible, given their established roles in inflammatory signaling and epithelial junction regulation, respectively [59, 71, 72]