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doi: 10.1186/s13045-018-0664-7 13 LiJCaoPChenYWangJSunXChenRet al

But promising results in rats do not reliably predict what will happen in people

For adults considering this therapy, understanding what realistic before and after results look like is essential for setting appropriate expectations

Notably, participants treated with metformin in the Multi-Ethnic Study of Atherosclerosis (MESA) study exhibit significantly elevated Lac-Phe levels compared to non-metformin users (Li et al., 2024)