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2002 Aug;77(8):754-9

Aromatase inhibitors are a class of compounds that may suppress estrogen production by ectopic endometrial tissue (Schenken 2012)

When sperm counts are significantly low, intracytoplasmic sperm injection (ICSI) and assisted reproductive technologies (ART) should be considered as a first treatment option

If true, this would suggest that all four PUFs provide target redundancy to ensure robustness to regulating the GSC proliferation vs differentiation balance within the germline (Table 1)