when patients exceed their broken and limited energy envelope, their cells rapidly switch to anaerobic glycolysis
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It's important to note that while these preclinical findings are compelling, human clinical trials remain limited
In SURPASS-2, which compared tirzepatide to semaglutide (a GLP-1 receptor agonist) in patients taking metformin, tirzepatide 5 mg, 10 mg, and 15 mg doses achieved mean HbA1c reductions of 2.01%, 2.24%, and 2.30% respectively from baseline, compared to 1.86% with semaglutide 1 mg