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Multidrug resistance-associated proteins: expression and function in the central nervous system

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Both drugs showed significant antitumor activity, with serum asparaginase activity (SAA) 0.1 UI/ml (considered therapeutic) in 95% of patients in both groups after 18 days of treatment and 25 days after treatment

When it is used for a long period of time, it can cause kidney failure by causing renal toxicity or dysfunction, especially in uncontrolled dosage