Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis
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Importantly, older adults adhere better to, and maintain greater weight loss from, lifestyle interventions [70,71,72], and in the real-world setting, the National Institute for Health and Care Excellence (NICE) report that older participants lose more weight than younger adults during BWMPs [73]