Disrupted red blood cells can ultimately lead to iron deficiency anemia, which often results in feelings of tiredness, weakness, and a lack of energy
Scott Isaacs, MD, FACP, FACEs Post This NEJM Perspective highlights a growing problem with GLP-1 therapy: rising off-label, lifestyle use, little eating-disorder screening, and millions at risk of silent harm if we do not build safeguards now
Natural GLP-1 is rapidly broken down, so drug developers created longer-acting receptor agonists that reproduce selected GLP-1 effects over a longer period
Many cases involve children or infants whose parents accidentally measure the wrong dose in the middle of the night, or combine different medicines without realizing that they all contain the same ingredient -- for example, Tylenol for a fever and then a second medicine for a cough
However, for other conditions like atherosclerotic disease and stroke, observational and Mendelian-randomization evidence is mixed, with studies showing positive, inverse, or null associations depending on the specific endpoint