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L-NNA, added to PTX, caused a small but not significant increase in the plasma TNFalpha and this effect was attenuated by addition of L-arginine to L-NNA in PTX-treated animals ( Fig

These regulatory effects are demonstrated to co-regulate the downstream glutamine metabolism targets and to show their effects on cancer cell invasion and metastasis

There are several hypotheses for the second signal activation and further investigations are necessary in order to find whether is there any common component for all second signals described, for example, the release of ROS 93

Creatine supplementation, when combined with resistance training, may increase lean mass and muscle strength