Don't Let Yourself Be Fooled & Scammed One thing I have to point out in a big way if you are at this point- frustrated with your weight loss journey and thinking about Tirzepatide or Semaglutide you are bound to see some ADS by some semi-big brands suggesting that bio-identical hormonal replacement treatment is the answer INSTEAD OF these weight loss peptides
Thanks to the weight loss effect of once-weekly incretin-based therapies such as semaglutide and tirzepatide, a disease-centric approach to the management of type 2 diabetes mellitus (T2D) has now become more attainable, and patients are initiating requests for these therapies
At the cellular level, GLP-1 agonists exert several beneficial effects: Cardiomyocyte protection : GLP-1 agonists inhibit receptor-interacting protein kinase 3/mixed lineage kinase domain-like pseudokinase-mediated myocardial necroptosis by activating the GLP-1R/PI3K/Akt pathway [5] Anti-fibrotic effects : These agents alleviate cardiac fibrosis and hypertrophy by upregulating atrial natriuretic peptide expression, which suppresses the calcineurin/nuclear factor of activated T cells 3 signaling pathway [5] Cellular stress reduction : GLP-1 agonists diminish endoplasmic reticulum stress and enhance autophagy in cardiomyocytes, preventing apoptosis and blocking progression to heart failure [5] Vascular effects : In vascular smooth muscle cells, GLP-1R activation primarily leads to Gs-mediated cAMP/PKA signaling while simultaneously inhibiting pro-proliferative pathways including ERK1/2 and p38 MAPK [4] Beyond these direct cellular effects, GLP-1 agonists improve cardiac function through multiple systemic mechanisms
Compared with both placebo and liraglutide at 26 weeks, orally bioavailable semaglutide is superior in reducing BW and non-inferior to liraglutide concerning for decreasing HbA1c [21]
it's the entire foundation upon which credible discoveries are built
