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Animal studies have shown that TMAO induces vascular inflammation by activating the sirtuin 3 -superoxide dismutase 2- mitochondrial ROS (SIRT3SOD2mtROS) and stimulating in vitro and in vivo formation of the NLRP3 inflammasome (Seldin et al., 2016)

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This stigma isnt without cause, as 26% of the 2,000 people surveyed said they would not date someone taking a GLP-1 and a further 29% were unsure

The effects persisted beyond the peptide's pharmacokinetic half-life, supporting the "trigger" hypothesis (PMID 514474)