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Mutt and Jorpes were involved in the extraction and purification of biologically active gastrointestinal peptides, including secretin and CCK, from animal tissues

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The key variable was maintaining that 7-day interval

Butyrate as Therapy Conclusions Butyrate has long been known as a microbial fermentation product of dietary fibers in the gut, and references of butyrate-producing bacteria isolated from dietary sources emerged already in late 1940 (111)