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Why GLP-1 Medications Cause Constipation GLP-1 receptor agonists slow gastric emptying and reduce small intestinal motility as part of their core mechanism, and constipation appears as a common adverse event in their FDA prescribing information.[1] The slowing happens throughout the upper GI tract, transit times extend, the colon has more time to absorb water from stool, and bulk that normally drives colonic propulsion is reduced because food intake also drops

Below is a comparison highlighting their unique contributions: In weight loss regimens, B6 helps manage treatment side effects, while B12 ensures energy levels remain stable and metabolic processes function effectively

Zepbound may increase hypoglycemia risk when used with insulin or sulfonylureas, potentially requiring dose adjustments of these medications

It must be used in combination with other injectable drugs

The recommended dosage is 1.75mg injected under the skin