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Morever, due to its anticoagulant properties (Mast, 2016), TFPI could be seen as a positive aspect in the context of COVID-19 treatment, albeit potential clinical applications have to be carefully evaluted due to its reported role in cancer ( Combined Therapeutic Potential Targeting RAAS and DPP4 DPP4 signalling and RAAS dysregulation bidirectional crosstalk has been proposed previously