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these medications may need dose adjustment Increased heart rate, typically a modest elevation Dehydration risk, especially with persistent vomiting or poor fluid intake, which can lead to acute kidney injury According to MHRA guidance, rare but serious adverse effects include acute pancreatitis (inflammation of the pancreas), gallbladder disease including cholelithiasis (gallstones), and thyroid C-cell tumours (observed in rodent studies

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You do get peaks and troughs, so some people get big effects right in the beginning, and it starts to taper off towards the end of the week

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