No transdermal GLP-1 patch is FDA approved for weight loss
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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%
However, the overall inhibition was limited, likely attributable to their insufficient atherosclerosis accumulation due to the absence of platelet carriers
A review of 29 studies of patients that underwent bariatric surgery showed a significant improvement in liver function tests and a meta-analysis reported a decrease in steatosis, inflammation, and fibrosis [9, 10]