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Central estrogen receptor alpha (ER-alpha) signaling is necessary for GLP-1 to fully exert its effects on food-reward behavior

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Grafik 1 (oben) illustriert, dass seit der Einfhrung des ersten GLP-1-RA Exenatide (2006) die Entwicklung zu immer wirkstrkeren Substanzen gefhrt hat, gemessen an einer Reduktion des HbA1c (20, 21, 26, 27, 28, 29, 30, 31, 32)