Proc Natl Acad Sci U S A 106:1140011405 Subburayan K, Thayyullathil F, Pallichankandy S, Cheratta AR, Galadari S (2020) Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
You may remember that Avandia was actually pulled from the market because of increased heart failure risk, and that this led to a revolution in diabetes care prioritizing cardiovascular safety before diabetes drugs could be FDA approved
Still, in the process, it can create Superoxide, oxygen with too many electrons that is poisonous to everything around it, be it mitochondria, DNA, proteins, cell membranes, etc
Nausea, gastrointestinal discomfort, and fatigue are the most common GLP-1 side effects, and theyre driving much of the interest in GLP-1 microdosing
S.PadilhaM.et al