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For assessment of glucose-induced insulin secretion, glucose was given orally at a dose of 4 g kg 1 in 6 h fasted mice, followed by blood sampling at timepoints 0, 2, 5, 15 and 30 min after glucose administration

In this context, there are three practical questions a COA may help answer: Identity: Does the sample contain the compound claimed on the label

in contrast, T2DM patients often present with DKD at the time of their first diagnosis, as both conditions tend to go unnoticed for long periods [105]

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However, there are some key differences in terms of how quickly they work and their overall effectiveness