Meta-analyses confirm that curcumin significantly lowers BMI and improves glucose metabolism by reducing fasting plasma glucose, insulin levels, HOMA-IR, total cholesterol, and CRP (126)
However, a study indicated that estrogen downregulates clusterin gene expression in the rat endometrium (76), which appears to contradict the anti-inflammatory effects of estrogen
Almanac Clin Med
L-carnitine also may help reduce lactic acid accumulation and support a higher lactate threshold, but most importantly, it may help reduce mental fatigue
So where I've seen people push back is they will acknowledge if confronted with those data, they'll acknowledge it, but they'll say that, Hey, those data are based on hemoglobin A one C and not C G M, to which I'll say, yeah, that's true