On the one hand, it plays a role through weight-dependent pathways, reducing food intake in the central nervous system and reducing the level of growth hormone-releasing peptides, while delaying gastric emptying and synergizing with GLP-1 to promote weight loss
Many patients eventually reduce their dose, switch to maintenance-level dosing, or transition off the medication entirely
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Thats nearly the same as injectable Wegovy, with an average weight loss of about 15%
For example, many patients in dedicated HF studies do not have diabetes and, depending on the study, have either HFrEF or HFpEF (Fig