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The lack of evidence is not surprising given the many definitions of the disorder employed and the focus of most trials on National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) diagnostic criteria (note that the NIDDK diagnostic criteria are not appropriate for use outside of clinical trials)

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Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner