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Moreover, intra-articular injection of monoiodoacetate (MIA) induces loss of articular cartilage with subchondral bone lesions that mimic those of human OA and This model offers a rapid and minimally invasive method to reproduce OA-like lesions in a rodent species [13]

Pyroptosis inhibitors AVE0991 inhibits the ROS-NLRP3 pathway, reducing GSDMD-mediated hepatocyte pyroptosis [37]

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